Does Depletion of Three BMP Antagonists from Spemann\'s Organizer Lead to a Cata

Question

Does Depletion of Three BMP Antagonists from Spemann's Organizer Lead to a Catastrophic Loss of Dorsal Structures? Are there any future experiments that you think could be done to continue the work? Explain and provide your person opinion on this matter. Does Depletion of Three BMP Antagonists from Spemann's Organizer Lead to a Catastrophic Loss of Dorsal Structures? Are there any future experiments that you think could be done to continue the work? Explain and provide your person opinion on this matter. Does Depletion of Three BMP Antagonists from Spemann's Organizer Lead to a Catastrophic Loss of Dorsal Structures? Are there any future experiments that you think could be done to continue the work? Explain and provide your person opinion on this matter.

Explanation / Answer

Transplanted Spemann's organizer induces dorsal embryonic cell fate such as the nervous systen and somites.but in normal devlopment,elimination of individual organiser signals (such as bone morphogenetic protein (BMP)antagonists) has surprisingly modest effect on these tissues.thus therole of BMP antagonists may be limited to fine tuning the size of the ddorsal domain.Antagonists are specially expressed in the organiser, and all can mimic aspects of organiser function and overlapping function.hence researcher deplete tge function of three BMP antagonists,chordin,noggin,and follistatin in xenopus tropicals.researcher demonstrate that this result of catastrophic faliure of dorsal devlopment and expansion of ventral and posterior fates.researcher think tbat BMP antagonists are required for formation of neural specification requires the continuous activity of BMP antagonists from blastula through gastula stages.

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