Duchenne Muscular Dystrophy is an inherited sex-linked recessive disorder. Indiv

Question

Duchenne Muscular Dystrophy is an inherited sex-linked recessive disorder. Individuals with this disorder have a progressive breakdown, or dystrophy, of a protein involved with muscle stability. The gene for this protein, dystrophin, is found on the X-chromosome. An unaffected male has a wife who is unaffected, but is a carrier for this disorder.

Complete a Punnett Square for this couple to determine the chance of their children being affected. Be sure to use the correct genotype symbols for parents and offspring in your Punnett Square.

Describe the expected phenotypes of the offspring, including the chance (ratio or percent) of that phenotype.

Answers should refer seperately to sons and daughters, and include whether their phenotype is “affected” or “unaffected”, and “carrier”, or “non-carrier” of the disorder.

Explanation / Answer

Present Scenario:

Unaffected Male: XY

Carrier Female: XXr , where Xr is affected

Punnet Square:

XX: Unaffected female: 1/4

XY: Unaffected male: 1/4

XXr: Carrier female: 1/4

XrY: Affected Male: 1/4

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