2)What change do you propose to make the vaccine formulation to induce a better

Question

2)What change do you propose to make the vaccine formulation to induce a better immune response ?

3)Your co worker decieded to revisit the option of making a live attenuated vaccine using a weakend form of this virus....

4) Your manager knows that the company is striving hard to implement alternative vaccine

(15 pts) ecently, you were hired by the biotechnology No to help develop a new company e against Marburg virus (a Hemorrhagic Fever Virus similar to has identified Ebola). To the company and purified both key polysaccharide and polypeptide molecules from the Marburg virus glycoprotein (MGP). MGP is a key virulence factor involved in receptor binding and virus-host membrane fusion, so these two molecules are hypothesized to be good candidates for use in developing a vaccine against Marburg virus. However, initial in vivo experiments using vaccine formulations containing each of these molecules alone showed a poor immune response in the animal model. Your manager has asked you to investigate one of these molecules (your choice) and determine a way to make it more immunogenic. The other molecule will be investigated by one of your coworkers. a) (4 pts) Which molecule do you choose to investigate? What key signal is missing from the current vaccine formulation containing the single molecule? b) (3 pts) What change do you propose to make to the vaccine formulation to induce a better immune response

Explanation / Answer

1. The polypeptide is good choice to initiate the vaccine trials against this disease. The key features in eliciting a good response include many different factors like retention of this antigen in the blood for a longer which is achieved by the slow release, the molecular weight of the polypeptide as more the big it is the best immune response you can elicit.

The key feature missing from the vaccine formulation would be addition of an adjuvant which makes it to release the antigen into the blood stream slowly and this will elicit a robust immune response.

2. Getting a robust immune response would be possible by changing the vaccine formulations like making the antigen release slowly from the formulation by mixing it well with an adjuvant. Making sure the polypetide is long enough to induce a robust immune response.

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