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A protein binding site contains a pocket lined with several amino acids that hav

ID: 813305 • Letter: A

Question

A protein binding site contains a pocket lined with several amino acids that have nonpolar side chains. Assuming a good spatial fit, which kinds of functional groups are best suited for placement in this pocket in order to enhance the binding of a ligand?

A protein binding site contains a pocket lined with several amino acids that have nonpolar side chains. Assuming a good spatial fit, which kinds of functional groups are best suited for placement in this pocket in order to enhance the binding of a ligand?

positively charged groups

nonpolar groups.

polar groups.

negatively charged groups.

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Part C

A protein binding site contains a pocket that is dominated by an amino acid with a positively charged side chain.  Assuming a good spatial fit, which functional groups in the list below are best suited for placement in this pocket in order to enhance the binding of a drug?

A protein binding site contains a pocket that is dominated by an amino acid with a positively charged side chain.  Assuming a good spatial fit, which functional groups in the list below are best suited for placement in this pocket in order to enhance the binding of a drug?

positively charged groups

nonpolar groups.

polar groups.

negatively charged groups.

Explanation / Answer

nonpolar groups.

c) -COO?

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