Enzymes play essential roles in many functions of cells, organs and organisms. T
ID: 79553 • Letter: E
Question
Enzymes play essential roles in many functions of cells, organs and organisms. The diagram below represents a hypothetical enzyme protein with 100 amino acids. The number scale indicates the position of each amino acid. Below the protein representation is an annotation that describes the function of the indicated amino acids in this protein. This enzyme is regulated by an allosteric inhibitor. What would be the likely effect on this enzyme's activity if there were a point insertion mutation in the codon for the amino acid at position 23? Justify your answer with a brief description. What would be the likely effect on this enzyme's activity if there were three separate deletion mutations in the codon for the amino acids between position 7 and 15? Justify your answer with a brief description. What would be the likely effect on this enzyme's activity if there were a substitution mutation in the second base in the codon for the amino acid at position 50? Justify your answer with a brief description.Explanation / Answer
Answer
If there is insertion mutation in the codon in the position of 23 amino acid, entire frame will be a shift so the amino acid from 23 onwards of given enzyme will be completely changed because of a frameshift mutation. So enzyme may loose the activity since both the site, active as well as the regulatory site will be changed.
If there were three separate deletion mutation in the codon between amino acid 7 to 15 then enzyme will be three amino acid shorter but the function of enzyme remain unchanged due to fact that deletion mutation of the whole codon will not shift the frame and moreover this has not happened in the region of active site of regulatory site. So there will not be any change in the activity of the enzyme.
There will not be any apparent effect of the activity of enzyme if substitution occurs at position 50 of amino acid since the position is not coming either at activity site or regulatory site.
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