Which of the following is NOT part of the sequential mutation model of the devel

Question

Which of the following is NOT part of the sequential mutation model of the development of colorectal cancer? mutations that promote metastasis ras mutation promoting cell division p53 or mutation leading to malignancy mutation in telomerase promoting tissue invasion Actually, all of these are part of the model. All of the following chromosome structure changes can lead to cancer EXCEPT deletions of regions that contain tumor-suppressor genes. duplications leading to increase of oncogene products. inversions leading to inactivation of tumor-suppressor genes. translocations leading to aberrant fusion proteins. Actually, all of these lead to cancer. Certain viruses known to be associated with or cause cancer to include all of the following EXCEPT: HTLV-1, a retrovirus that causes T-cell leukemia. hepatitis B, which can cause liver cancer. papilloma virus, which can cause cervical cancer. Epstein-Barr virus, which can cause leukemia. Actually, all of these are known to cause cancer.

Explanation / Answer

10.d temerase mutation is not in the pathways of colorectal. IT occurs independently in all camcer types.

11. D aberrant protein formation due to translocation may render a cell functionless or death. But it wont turn into cancer

12. B. Hepatitis B causes lung damage but not directly associated with lung cancer.

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