Pepsin is the name given to a mix of several digestive enzymes secreted ( as lar

Question

Pepsin is the name given to a mix of several digestive enzymes secreted ( as large precursor proteins) by glands that line the stomach. The glands also secrete hydrochloric acid, which dissolves the particulate matter in food, allowing pepsin to enzymatically cleave individual protien molecules. The resulting mixture of food, HCL, and digestive enzymes is known as chyme and has a pH near 1.5. What PI would you predict for he pepsin protein. What functional groups must be present to confer this pI on pepsin? Which amino acids in the proteins would contribute such groups?

I know the first answer is around 1 but can someone explain how we would predict that from this question?

Explanation / Answer

Pepsin proteins have a relatively low pI (near the pH of gastric juice) in order to

remain soluble and thus functional in the stomach. (Pepsin

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