Pepsin, a protelytic enzyme, cleaves the heavy chains at thehinge region. Given

Question

Pepsin, a protelytic enzyme, cleaves the heavy chains at thehinge region. Given what you know about the molecule, why does thisseem like the obvious place that an enzyme would act to you? Why isit called the "hinge" region? Any suggestions/ideas? Please help thanks! Pepsin, a protelytic enzyme, cleaves the heavy chains at thehinge region. Given what you know about the molecule, why does thisseem like the obvious place that an enzyme would act to you? Why isit called the "hinge" region? Any suggestions/ideas? Please help thanks!

Explanation / Answer

http://www.infoplease.com/ce6/sci/A0838243.html They have information there. pepsin, enzyme produced in the mucosal lining ofthe stomach that acts to degrade protein. Pepsin is one of threeprincipal protein-degrading, or proteolytic, enzymes in thedigestivesystem, the other two being chymotrypsinand trypsin. Thethree enzymes were among the first to be isolated in crystallineform. During the process of digestion, these enzymes, each of whichis particularly effective in severing links between particulartypes of amino acids, collaborate to break down dietary proteins totheir components, i.e., peptides andaminoacids, which can be readily absorbed by the intestinal lining.In the laboratory studies pepsin is most efficient in cleavingbonds involving the aromatic amino acids, phenylalanine,tryptophan, and tyrosine. Pepsin is synthesized in an inactive formby the stomach lining; hydrochloric acid, also produced by thegastric mucosa, is necessary to convert the inactive enzyme and tomaintain the optimum acidity (pH 1–3) for pepsinfunction. Pepsin and other proteolytic enzymes are used in thelaboratory analysis of various proteins; pepsin is also used in thepreparation of cheese and other protein-containing foods. Hope it helps Please rate

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