How do the molecular responses to histamine differ if histamine binds to the H1
ID: 78982 • Letter: H
Question
How do the molecular responses to histamine differ if histamine binds to the H1 vs. H2 receptor, what characteristic of signaling is this phenomenon an example of (i.e. amplification, integration, modularity, and how do the different receptors contribute to signaling specificity?
How do the molecular responses to histamine differ if histamine binds to the H1 vs. H2 receptor, what characteristic of signaling is this phenomenon an example of (i.e. amplification, integration, modularity, and how do the different receptors contribute to signaling specificity?
Explanation / Answer
The histamines play important role in immunity. They are secreted by mast cells and basophylls eliciting allergic reactions of skin and tissues. They bind to 4 receptors h1 to h4 and elicit various metabolic and biochemical signal cascade.
Binding of histamine to H1 receptor couples to Gq/11 stimulating phospholipase C. It is a G couples receptor which modulates multiple functions. It involved in sleep wake cycle, memory, visual learning.. etc. The H2 receptor on the pther hand activates the cAMP which intern activates protein kinase A thus amplifying the signal down the signal cascade. The H2 is involved in multiple function such as smooth muscle relaxation, gastricjuice secretions.. etc.
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