How do the nanosensors in the 2016 ACS Nano study \"Diagnosis and Classification

Question

How do the nanosensors in the 2016 ACS Nano study "Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules" measure only 13 VOCs when there are hundreds of VOCs in a breath sample?

GCMS analysis of breath highlights 13 VOCs as indicating disease, but how is a nanosensor able to measure only those 13 VOCs and avoid all others?

For more background refer to the article . . Nakhleh, M.K.; Amal, H.; Jeries, R.; Broza, Y.Y.; Aboud, M.; Gharra, A.; Ivgi, H.; Khatib, S.; Badarneh, S.; Har-Shai, L.; Glass-Marmor, L.; Lejbkowicz, I.; Miller, A.; Badarny, S.; Winer, R.; Finberg, J.; Cohen-Kaminsky, S.; Perros, F.; Montani, D.; Girerd, B.; Garcia, B; Simonneau, G.; Nakhoul, F.; Baram, S.; Salim, R.; Hakim, M.; Gruber, M.; Ronen, O.; Marshak, T.; Doweck, I.; Nativ, O.; Bahouth, Z.; Shi, D.; Zhang, W.; Hua,Q.; Pan, Y.; Tao, L.; Liu, H.; Karban, A.; Koifman, E.; Rainis, T.; Skapars, R.; Sivins, A.; Ancans, G.; Liepniece-Karele, I.; Kikuste, I.; Lasina, I.; Tolmanis, I.; Johnson, D.; Millstone, S.J.; Fulton, J.; Wells, J.W.; Wilf, L.H.; Humbert, M.; Leja, M.; Peled, N.; Haick, H. Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules. ACS Nano 2017 11, 112-125DOI: 10.1021/acsnano.6b04930

Explanation / Answer

In GCMS analysis there are mainly 2 steps. In the first step, the sample goes through the GC capillary column and velocity of molecule is mainly depends upon the chemical properties of the molecule. Therefore all the different molecules will go out of the column at different time intervals. Separation of the mixture allows the MS to capture, ionize, accelerate, deflect, and detect the ionized molecules separately. This will be done by just breaking each molecule into ionized fragments, which detects using their mass to charge ratio. The final chromatogram mainly depends upon the retention time to the abundance of each compound. The area under the curve for a specific compound is proportional to its concentration in the mixture.

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