DNA chains are extended on a template and from a primer with a(n) [____] in the
ID: 74787 • Letter: D
Question
DNA chains are extended on a template and from a primer with a(n) [____] in the 5 to 3 direction, allowing the chain to continue elongation when a mistake in polymerization has been removed by [____]. In this case, the energy for the corrected nucleotide polymerization is provided by the [____] deoxyribonucleotide triphosphate. If the DNA chain extension proceeded in a [____] direction, the energy would have to be provided by the [____] deoxyribonucleotide triphosphate, thereby blocking further repair and polymerization.
(1) RNA; DNA ligase; incoming; 5 to 3; polymerized
(2) free 5 OH; DNA polymerase; departing; 3 to 5; incoming
(3) overhang; uracil-DNA glycosylase; polymerized; 5 to 3; departing
(4) free RNA 3 OH; endonucleolytic proofreading; departing; 3 to 5; incoming
(5) free 3 OH; exonucleolytic proofreading; incoming; 3 to 5; polymerized
Explanation / Answer
(5) free 3 OH; exonucleolytic proofreading; incoming; 3 to 5; polymerized
DNA chains are extended on a template and from a primer with a(n) [_free 3' OH___] in the 5 to 3 direction, allowing the chain to continue elongation when a mistake in polymerization has been removed by [_exonucleolytic proofreading___]. In this case, the energy for the corrected nucleotide polymerization is provided by the [_incoming___] deoxyribonucleotide triphosphate. If the DNA chain extension proceeded in a [_3' to 5'___] direction, the energy would have to be provided by the [_polymerized___] deoxyribonucleotide triphosphate, thereby blocking further repair and polymerization.
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