DNA chains are extended on a template and from a primer with a(n) [____] in the
ID: 57151 • Letter: D
Question
DNA chains are extended on a template and from a primer with a(n) [____] in the 5 to 3
direction, allowing the chain to continue elongation when a mistake in polymerization has been removed
by [____]. In this case, the energy for the corrected nucleotide polymerization is provided by the
[____] deoxyribonucleotide triphosphate. If the DNA chain extension proceeded in a [____]
direction, the energy would have to be provided by the [____] deoxyribonucleotide triphosphate,
thereby blocking further repair and polymerization.
(1) RNA; DNA ligase; incoming; 5 to 3; polymerized
(2) free 5-OH; DNA polymerase; departing; 3 to 5; incoming
(3) overhang; uracil-DNA glycosylase; polymerized; 5 to 3; departing
(4) free RNA 3-OH; endonucleolytic proofreading; departing; 3 to 5; incoming
(5) free 3-OH; exonucleolytic proofreading; incoming; 3 to 5; polymerized
Explanation / Answer
(4) free RNA 3-OH; endonucleolytic proofreading; departing; 3 to 5; incoming
DNA chains are extended on a template and from a primer with a(n) [__Free RNA 3-OH__] in the 5 to 3 direction, allowing the chain to continue elongation when a mistake in polymerization has been removed by [__endonucleolytic proofreading__]. In this case, the energy for the corrected nucleotide polymerization is provided by the [__departing__] deoxyribonucleotide triphosphate. If the DNA chain extension proceeded in a [__ 3 to 5__] direction, the energy would have to be provided by the [__incoming__] deoxyribonucleotide triphosphate, thereby blocking further repair and polymerization.
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