In order to demonstrate positive thymic selection experimentally, researchers an

Question

In order to demonstrate positive thymic selection experimentally, researchers analyzed the thymocytes from normal H-2b mice, which have a deletion of the class II IE gene, and from H-2b mice in which the class II IA gene had been knocked out.

What MHC molecules would you find on antigen-presenting cells from the normal H- 2b mice?

What MHC molecules would you find on antigen-presenting cells from the IA knockout H-2b mice?

Would you expect to find CD4+ T cells, CD8+ T cells, or both in each type of mouse? Why?

Explanation / Answer

MHC II and or MHCI Molecules will be found on antigen presenting cells from normal H-2b mice.because presence of class I or II molecule is necessary for survival.and normal mice will express both molecule.this will express both CD4 and CD8 CELLS.

B. Only class I MHC will be found on knockout mice and will express CD4 cells.

C.In normal mice there will be both type of cells CD4 and CD8 Cells

There will be CD8+ Cells in knockout mice.

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