Huntington\'a Chore is a nervous disorder characterized by convulsions and vario

Question

Huntington'a Chore is a nervous disorder characterized by convulsions and various mental problems. the age of onset of symptoms varies, but is usually between 30 and 40 years of age. the gene causing this condition is dominant (H) to the normal gene(h). the late folk singer Woody Guthrie was afflicted with Huntington's Chorea. His wife is completely normal (hh) Since this gene is relatively rare in the population, it is likely that Woody was heterozygous (Hh) rather than homozygous (HH). What are the chances that Woody's son, Arlo, will develop Huntington's Chorea sometime during his lifetime?

Explanation / Answer

Cross between heterozygous father (Hh) and homozygous recessive mother for the Huntington's Chore (H) gene will have the offspring with the following genotypes.

Hh* hh = Hh, Hh, hh, hh. So, 50% of their offspring will be affected and another 50% are normal. Of the 50% affected children, the chances of having son is 1/2.

Thus, the chances that Woody's son, Arlo, will develop Huntington's Chorea sometime during his lifetime = 1/2* 1/2 = 1/4 or 25%.

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