Huntington?s disease, a dominantly inherited genetic disease that causes degener

Question

Huntington?s disease, a dominantly inherited genetic disease that causes degeneration of neurons, runs in Maria?s family. Family members that have the disease include Maria?s paternal grandmother and Maria?s paternal uncles. Maria?s paternal grandfather does not have the disease. Because symptoms of Huntington?s disease do not appear until later in life, 9enetic testing is necessary to determine whether a younger individual possesses the allele for the disease. These tests determined that Maria?s father does not carry the allele for Huntington?s disease. Maria?s maternal under suggested that Maria create a pedigree to track the disease in her family. Use the symbols provided to complete the pedigree. Each symbol may be used more than once.

Explanation / Answer

In the given case study, it is mentioned that Huntington’s disease is a dominant disease. Maria paternal grandmother and her paternal uncles are suffering with this disease. This disease is expressed in the old age hence; her father is tested for diseased condition which proved he is normal. Thus, it indicates her paternal grandmother is a carrier but not homozygous for the disease.

In the given condition, none of her maternal family members are mentioned as sufferers. Hence, all the offsprings of her maternal grandparents will be normal. Thus, when normal male and normal female are crossed no offspring will be a sufferer.

Similarly, as parents of Maria are normal she would not be a sufferer of the Huntington’s disease.

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