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Insulin binds to the insulin receptor on many cells. The direct outcome of this

ID: 64523 • Letter: I

Question

Insulin binds to the insulin receptor on many cells. The direct outcome of this is that the number of glucose transporters in the plasma membrane increases leading to increased glucose uptake. Signaling through the insulin receptor also triggers activation of enzymes associated with glycolysis (sugar breakdown) as well as glycogen synthesis (sugar synthesis and storage) and fatty acid synthesis (this should seem odd). Why does this make sense? That is, provide an explanation that reconciles these observations.

Explanation / Answer

The glucose taken up by the cells is broken down through glycolysis. This gives ATP. The synthesis of glycogen is storage of excess glucose. If glucose is really in excess, then fat synthesis occurs. Fatty acids cause the formation of fat. This fat can be broken down to form glucose in times of need.

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