Insulin can be considered to be a classic endocrine substance: produced at one d

Question

Insulin can be considered to be a classic endocrine substance: produced at one discrete location in the body, then being distributed via the bloodstream to the numerous sites where it stimulates its important metabolic effects. Normally, this discrete location is the endocrine pancreas. For an external insulin infusion pump to deliver insulin with the desired therapeutic effect, what must be true about the fate of insulin after it is injected by the pump into the interstitial space under the skin?

Explanation / Answer

The subcutaneou route is the one of the most versatile routes for administration that can be used for both short term and long term therapies .The injection of drug or implantation of a device device made in loose interstial tissue of he upper arm,anterior surface of the thigh or lower portion of the abdomen ,the subcutaneous tissue is influenced by the same factors that determine rate of absorption from the intramuscular sites ,how ever the vascularity of the subcutanoues tissue is less than that of the muscle tissue therefor absorption is lower than the intramuscular .the drug should be given in small amounts and it should be soluble.

contineous subcutanoeus insulin infusion from an infusion pump depends on the reliable transfer of the pumped insulin to the subcutaneous insulin depot ,the traditional pump is connected to patients via thin ,soft ,felxible plastic tubing ,insulin is pumped through the infusion set into SC layer to induce the metabolic effect ,lower infusion rates cover basal insulin requirement .while high rates are given for the prandial insulin requirement and hyperglycemeia .

Related Questions

Navigate

• Browse (All)
• Browse I
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.