As a new graduate student, you have been tasked with studying how multiple local

Question

As a new graduate student, you have been tasked with studying how multiple localization signals affect the localization of proteins in cells. To do this, you have engineered a set of genes that code for a protein that contains two different signal sequences on the same polypeptide. Predict the ultimate localization of a protein that contains the following two signal combinations on the same polypeptide and in 1 sentence, state the molecular reason why your protein will go where you say it will go.

A. ER signal sequence and a Mannose-6-phosphate site

B. ER stop transfer sequence and an NLS

C. Mitochondrial signal sequence and an ER-retention signal sequence

D. Mannose-6-phosphate site and an NLS.

E. NLS and an ER signal sequence on the very last amino acids

Explanation / Answer

Answer:

E. NLS and an ER signal sequence on the very last amino acids

Nuclear localization signals is needed for nuclear import. The main function of the nuclear import is translocate proteins that are formed from ribosomes after translation. Signal for import into Endoplamic Reticulum is located at N-terminal side of protein.

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