1. A colleague has carried out a genetic screen for mutations that decrease expr
ID: 60629 • Letter: 1
Question
1. A colleague has carried out a genetic screen for mutations that decrease expression of lipopeptide biosynthetic gene, sunA, in the bacterium S. coelicolor. This colleague tells you that she believes the mutations are in a gene for a small, non-coding RNA. She gives you a copy of the DNA sequence around the site of the mutation. Which of the following are NOT features that you would look for in this DNA sequence that would help convince you that there is a gene for a small, non-coding RNA
A. An open-reading frame that encodes for a protein
B. Lack of a ribosome-binding site
C. Sequence homology to the sunA gene.
D. A promoter sequence that could direct transcription
2. What effect can small, non-coding RNA have on genes that decreases their expression?
Choose all the apply
A. mRNA stability
B. mRNA degradation
C. translational repression
D.Translational activation
A. mRNA stability
B. mRNA degradation
C. translational repression
D.Translational activation
Explanation / Answer
1. According to the given data, we cannot look into the gene for an open-reading frame that encode for a protein.
Hence, the correct option is (A).
2. Small, non-coding RNA participates in mRNA degradation, and thus gene regulation.
Hence, the correct option is (B) mRNA degradation.
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