7. Questions 7.1. Which are the factors affecting drug oxidation? How to prevent

Question

7. Questions 7.1. Which are the factors affecting drug oxidation? How to prevent? 7.2. When adjusting the pH value of vitamin C injection with NaHCOs, what aspect you should pay attention to? Why? 7.3. What theoretical or experimental basis you depend on to design the Vitamin C injection formulation? 7.4. What is the water for injection? Which methods and equipment should be used when prepare for it? 7.5. What are the factors influencing the clarity of the injections. 7.6. Why spectrophotometry can be used in checking the color of injection? What is the purpose?

Explanation / Answer

7.1)

no clarity on wht factors as externally or in patient

if it is external factor it will be air, light, oxidizing agents, pH

light by using aber color bottels, air by tightly closing the containers, oxidizing agents should be relaced by antioxidents like vit-c Na2S2O5 etc pH by buffers

7.2)

NaHCO3 is an systamic alkalizer and a complete base so while adding base the acidity should not be changed the ph should be at a range of 5-7

7.3)

the composition of vit-c inj was vit-c NaHCO3 (pH adjustment), NaHSO3(Anti oxident)Di sodium EDTA(Metal complexing agent) water for injection

7.4)

Water for injection is a water of extra high quality without contamination of any microbes and dust particals, methods like filteration, deionisation, reverse osmosis, distillation etc,

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