1:Describe the five types of forces that are involved in stabilizing or destabil

Question

1:Describe the five types of forces that are involved in stabilizing or

destabilizing an alpha helix. Listing the forces is not enough, Please give specific details

about each one.

2: The dissociation constant (Kd) of the rat calmodulin protein for binding calcium ions is 1 x

10-6M. What does this mean?

A. Half of the available available calcium binding sites are occupied when the concentration

of calcium is 1 x 10-6M,

B. When the concentration of calmodulin is 1 x 10-6M, half of the available calcium binding

sites are occupied.

C. When the concentration of calcium is 1 x 10-6M, all of the available calcium binding sites

are occupied.

D. All of the available calcium binding sites are occupied when the concentration of calcium

is 0.5 x 10-6M

Explanation / Answer

The helix is stabilized by hydrogen bonding - Inter chain hydrogen bonding gives stability to the alpha helix, Amphipathic Index - In which hydrophobic amino acids are faced inside and polar amino acids lie out side of the helix. The different destabilizers are denaturing conations, ionic solutions where the alignment of the amino acids are altered which results in destabilization of protein.

2. Option A. Because it is a condition where half of the available calcium is bound to the calcium binding sites.

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