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2. Which alkyl bromide reacts fastest with sodium iodide in acetone: butyl bromi

ID: 589404 • Letter: 2

Question

2. Which alkyl bromide reacts fastest with sodium iodide in acetone: butyl bromide or neopentyl bromide? Both of these are primary alkyl bromides. Explain the difference in reactivity acetone: butyl bromide or Which alkvl halide reacted fastest with sodium iodide in butvl chloride? Explain how the nature of the leaving group affects the rate in the Sx2 reaction. 3. 4. How did the following changes affect the rate of reaction of 1-bromobutane with Nal: doubling the concentration of 1-bromobutane? Doubling the concentration of Nal? 5. Write a generalized rate expression for an SN2 reaction

Explanation / Answer

2) Butyl bromide reacts faster than neopentyl bromide . This is because neopentyl bromide has bulky environment which causes steric hindrance when reaction incoming nucleophile I- attacks.

3) Br- is better leaving group than Cl- . Hence butyl bromide reacts faster than butyl chloride

4) Rate = k [ 1-bromobutane] [ NaI]

Thus when 1-bromo butane is doubled rate is doubled

When NaI is doubled , rate is doubled

5) Rate = k [ alkyl halide] [ Nucleophile]

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