It is known that the manx allele in cats is an autosomal recessive lethal and is

Question

It is known that the manx allele in cats is an autosomal recessive lethal and is abbreviated "M". The manx allele interferes with normal spinal development, and cats with one copy of the manx allele have no tail (Manx is dominant for the tailless phenotype). A manx homozygote has extreme developmental abnormalities and does not survive. Normal cats have a tail and the normal allele is abbreviated "m". You are studying this trait in a population of wild cats

You observe that in the initial generation (G0), there are:

770 manx (tailless) cats

139 normal cats

You observe that in G1, there are:

655 manx (tailless) cats

730 normal cats.

A) Using the fitness of the heterozygote calculated above, what is the predicted frequency of the M allele in G2?

B) Using the fitness of the heterozygote calculated above, what is the predicted frequency of the m allele in G2?

Explanation / Answer

allele MM = lethal / not survive

allele Mm = Tailess

allele mm = Normal tail

In G1, there are:

655 manx (tailless) cats

730 normal cats.

In G2

Mm X mm

        M         m

m     Mm      mm

m     Mm      mm

the predicted frequency of the M allele in G2    P(M) = 1/2 =0.5

the predicted frequency of the m allele in G2     P(m) = 1/2 =0.5

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