A cysteine protease from a malaria parasite was recently isolated. A compound na

Question

A cysteine protease from a malaria parasite was recently isolated. A compound named P56 was found to inhibit the enzyme. Compounds of this type have the potential to be used as drugs to treat malaria. Data were plotted as shown below.

a) What kind of inhibitor is P56?

b) Use the equations of the lines provided to calculate KM and Vmax for the enzyme with and without the inhibitor.

Note: NO INHIBITOR EQUATION: y=1.93x + 2.25

INHIBITOR EQUATION: y=4.93x + 2.35

c) Calculate the value of K1 in the presence of 0.22 mm inhibitor.

Explanation / Answer

P56 is a competitive inhibitor of cysteine protease.

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