1. Explain why both phosphofructokinase and pyruvate are inhibited by high level

Question

1. Explain why both phosphofructokinase and pyruvate are inhibited by high levels of ATP

2. Indicate which of the conditions increase the activity of the glycolysis or gluconeogenesis pathways:

a) increase in ATP

b) increase in AMP                         

c) increase in F-2,6-BP                  

d) increase in citrate

e) increase in acetyl-CoA              

f) increase in insulin                                   

g) increase in glucagon                 

h) starvation                                    

I) fed state

Explanation / Answer

1) High levels of ATP inhibits the enzyme by decreasing its effinity for fructose 6-phosphate.

ATP binds to an allosteric site on the pyruvate kinase and thus bring tge reduction of its activity.

Answering only one question as per chegg policy

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