Drug Delivery Unit Acute coronary syndrom (ACS) is chest pain due to insufficien

Question

Drug Delivery Unit Acute coronary syndrom (ACS) is chest pain due to insufficient blood supply to the heart muscle and results from coronary artery disease. It is also called coronary heart disease. In the treatment of ACS, a two-channel infusion pump may be used to deliver heparin (a polysaccharide mixture that reduces blood coagulation) and Integrilin (eptifibatide – a cyclic heptapeptide that inhibits platelet aggregation) to a patient continuously. Desired doses to treat ACS for an adult male weighing 70. kg are 1000. Units/hr for heparin and 8.25 mg/hr for Integrilin. Integrilin is available as a 100. mL sterile water solution containing 75 mg eptifibatide. Heparin is available as a sterile water solution containing 1000. Units heparin/mL. [There are ~170 Units per every mg of heparin.] Determine the flow rate of each stream in units of mL/hr and the mass fraction of each component in each stream to treat a 70. kg adult male. [You may assume that all solutions have the density of water.]

Explanation / Answer

Flow rate of Heparin - 1mL/hr

Flow rate of eptifibatide - 11mL/hr

Mass fraction of Heparin - 0.059

Mass fraction of eptifibatide - 0.75

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