The reductionist view of tumors: a. does not take into account heterotypic signa

Question

The reductionist view of tumors:

a. does not take into account heterotypic signaling between diverse cell types within a tumor

b. Focuses on the paracrine and endocrine contribution to tumor growth

c. takes into account normal fibroblack and endothelial cells and their rol in tumor cell proliferation

d. illustrates that increased sensitivity toward apoptosis is a hallmark of all types of cancer

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Which of the following statements is true?

a. cancers of a particular tissue arre always similar

b. tumor development follows a process analogous to darwinian selection

c. tumorgenesis results from a single mutation

d. cancer cells demonstrate cell autonomy

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the term 'angiogenic switch refers to:

a. factor that limits the size of incipient neoplasms

b. the ability of cancer to overcome vascular quiescence

c. the regulated growth of vessels and parenchyma during organogenesis

d. the capacity for invasion and metastasis

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the work of hayflick identified senescence as an event in normal cells. tumor cells overcome this finite replicative potential through: telomere maintenance

a. telomoere maintenance

b. inactivation of ALT

c. Increasing tumor cell replicative abilities to 60-70 population doublings

d. activation of cellular proteases

Explanation / Answer

* a. does not take into account heterotypic signaling between diverse cell types within a tumor

* d. cancer cells demonstrate cell autonomy

* c. the regulated growth of vessels and parenchyma during organogenesis

* d. telomere maintenance

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