Deoxyribonucleotides, which are DNA precursors, are derived from ribonucleotides

Question

Deoxyribonucleotides, which are DNA precursors, are derived from ribonucleotides. Ribonucleotide reductase catalyzes the conversion. Answer the following five questions about ribonucleotide reductase. Which of the following are substrates of the ribonucleotide reductase reaction? Which of the following are products of the ribonucleotide reductase reaction? What is the best description for the reaction? What is the ultimate electron donor? Which of the following can directly donate an electron to ribonucleotide reductase?

Explanation / Answer

1. The substrate for ribonucleotide reductase reaction are ADP CDP GDP and UDP

3. Ribonucleotide reductase reaction mechanism starts by radical abstraction elimination of water molecule, hydrogen transfer to the ketyl radical and finally ends by oxidaion of disulfide bridge and concominant reduction of the substrate.

4. Ribonucleotide reductase catalyses the de novo synthesis of dNDPs. Catalysis of NDPs involves a reduction at the 2 carbon of ribose-5-phosphate to form the 2 deoxy derivative reduced dNDPs. The reduction is initiated with the generation of a free radical. Following the single reduction RNR requires electron donated from the dithiol groups of the protien thioredoxin. Regeneration of thioredoxin occurs when NADPH provides 2 hydrogen atoms that are used to reduce the disulfide groups of thioredoxin .

5. As said in the above answer thioredoxin will donate the electron.

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