Dentinogenesis imperfecta is a tooth disorder. The trait is inherited as an auto

Question

Dentinogenesis imperfecta is a tooth disorder. The trait is inherited as an autosomal dominant allele in humans. Assume that a male with dentinogenesis imperfecta, whose mother had normal teeth, married a woman with normal teeth. They had four children.
What is the probability that their first child will be a male with dentinogenesis imperfecta?
What is the probability that three of their four children will have the disease? Dentinogenesis imperfecta is a tooth disorder. The trait is inherited as an autosomal dominant allele in humans. Assume that a male with dentinogenesis imperfecta, whose mother had normal teeth, married a woman with normal teeth. They had four children.
What is the probability that their first child will be a male with dentinogenesis imperfecta?
What is the probability that three of their four children will have the disease?
What is the probability that their first child will be a male with dentinogenesis imperfecta?
What is the probability that three of their four children will have the disease?

Explanation / Answer

Autosomal diseases spread in normal inheritance pattern. Here the allele is dominant and so the pattern will be normal inheritance. When the male has dentinogenesis imperfecta but the mother has a normal teeth, probably the father of the male had inherited the dominant allele and has been passed on to him. He marries a woman with normal teeth and bears 4 children.

The probability therefore the first child will be a male is 0.5 and the male will have dentinogenesis imperfecta is 0.5. Together the probability is 0.25.

Similarly the probability that 3 of the 4 children will have this disease will be 0.5 for every child.

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