Deoxyribonucleotides, which are DNA precursors, are derived from ribonucleotides

Question

Deoxyribonucleotides, which are DNA precursors, are derived from ribonucleotides. Ribonucleotide reductase catalyzes the conversion. Answer the following five questions about ribonucleotide reductase.

Which of the following are substrates of the ribonucleotide reductase reaction? Which of the following are products of the ribonucleotide reductase reaction? UDP dTTP dADP GDP dADP GDP UDP dTTP What is the best description for the reaction? What is the ultimate electron donor? O group transfer O isomerization Ooxidation-reduction O hydrolysis O phosphorylation O FAD O NAD O NADPH O FADH2 O NADH Which of the following can directly donate an electron to ribonucleotide reductase? O NADPH 0 thioredoxin O NADH 0 thioredoxin reductase

Explanation / Answer

a. Both UDP and ADP are substrates for ribonucleotide reductase

b. Products of ribonucleotide reductase reaction: dADP (dTTP is synthesized by a different enzyme thymidylate kinase)

c. The reaction is an oxidation-reduction reaction;

d. The ultimate electron donor is NADPH

e. Thioredoxin (the dithiol groups can directly donate electrons, it is then reduced by NADPH)

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