Procedure Wear safety glasses during period and use gloves when handling any che

Question

Procedure Wear safety glasses during period and use gloves when handling any chemicals. All chemicals, reactions and procedures should be used or in the hood. All organic be in the unless otherwise stated. The following procedures are literature descriptions for the format on of Dulcin from Tylenol. The Preparation of Tylenol (part 1): Grind 4 tablets of Tylenol (500 mg of acetaminophen per tablet or an equivalent amount) using a mortar and pestle and place the powder in a 50-mL round bottom flask with a magnetic stir bar. To the powdered tablets add 15.5 mL of a 1M ethanolic NaOH solution. Fit the round bottom with a water condenser and bring to reflux. Maintain reflux for 15 minutes and then remove the flask from its heat source. To the hot solution add 2.1 mL of ethyl iodide and return to reflux for an additional 15 minutes. Filter the hot on under vacuum through a Buchner and into a 200 to 300-mL side arm flask containing a 40-mL mixture of ice and water. Collect the insoluble on the filter paper. The phenacetin, upon with the cold water, precipitates

Explanation / Answer

For transformation 1, the solvent to be used is sodium hydroxide. It will be able to abtract proton from alcohol group of Tylenol so that reaction can go to completion.

For transformation 2, base hydrolysis is preferred, So NaOH is used.

For transformation 3, Base has to be used, so NaOH can also be used.

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