1. The side chain of the glutamine cannot undergo ionization as resonance impart

Question

1. The side chain of the glutamine cannot undergo ionization as resonance imparts a partial double bond character to the C-N bond. What will be the primary type of interaction in aqueous solution for this side chain?

a) hydrophobic

b) dipole-dipole

c) hydrogen-bond

d) ionic

2. Histidine has an imidazole side chain with a pKa of 6.0 meaning it can be found in +vely charged protonated form and neutral non-protonated form as shown. What is the strongest way for it to interact with other molecules in the non-protonated form?

a) Charge-charge (ionic)

b) Hydrogen bond

c) Induced dipole

d) Van der Waals

Explanation / Answer

1)

Primary interaction in c)

Hydrogen bonding with water

2)

What is the strongest way for it to interact with other molecules in the non-protonated form?

Protonated molecule with non-protonated molecular interaction is induced dipole interaction

Answer is C)

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