The adenine nucleotide translocase (ADP-ATP translocase), a transporter located

Question

The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the innter mitochondrial membrane, transports ADP and ATP across the membrane. It is an antiporter. (Recall that these adenine nucleotides are negatively charged: ADP3- and ATP4-.)

Phosphate translocase is also located in the inner mitochondrial membrane. It transports H+ and phosphate (H2PO4-) across the membrane. It is a symporter.

Answer parts (a), (b), (c), and (d) below.

a) Which direction is ATP4- transported during times of active oxidative phosphorylation?

b) What drives the transport of adenine nucleotides?

c) What is the ratio of ADP to ATP transported by the adenine nucleotide translocase? That is, how many ADP are transported for each ATP transported?

d) What drives the transport of H2PO4- across the membrane? Which direction is it transported during oxidative phosphorylation?

The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. It is an antiporter. (Recall that these adenine nucleotides are negatively charged: ADP and ATP*+. Phosphate translocase is also located in the inner mitochondrial membrane. It transports H and phosphate (H2PO4) across the membrane. It is a symporter. Answer parts (a), (b), (G), and (d) below. (a) Which direction is ATP+ transported during times of active oxidative phosphorylation? into the mitochondrial matrix O there is no net flow of ATP4- O out of the mitochondrial matrix (b) What drives the transport of adenine nucleotides? O O O transport is coupled with ATP hydrolysis the electrochemical gradient (membrane potential) simple diffusion

Explanation / Answer

a) out of the mitochondrial matrix i.e. into the intermembrane space

b)the electrochemical gradient

c) 1 ADP+Pi = 1ATP thus, ratio is 1ADP:1ATP

d) H+ & H2PO4-   is transported into the matrix in a process driven by the proton gradient.

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