Bcl-2 is \"pro-survival\" because: A. it activates the PI3K/Akt pathway. B. it l
ID: 41087 • Letter: B
Question
Bcl-2 is "pro-survival" because:
A.
it activates the PI3K/Akt pathway.
B.
it lies downstream of various pro-apoptotic signals.
C.
it contains several BH (Bcl homology) domains.
D.
its normal cellular function is to initiate the formation of apoptosomes.
E.
its normal cellular function is to inhibit the formation of Bax/Bak channels within the mitochondrial outer membrane.
A.
it activates the PI3K/Akt pathway.
B.
it lies downstream of various pro-apoptotic signals.
C.
it contains several BH (Bcl homology) domains.
D.
its normal cellular function is to initiate the formation of apoptosomes.
E.
its normal cellular function is to inhibit the formation of Bax/Bak channels within the mitochondrial outer membrane.
Explanation / Answer
B. it lies downstream of various pro-apoptotic signals.
These are the apoptosis regulatory protein present in the body also called the proapoptotic proteins. these are classified under the oncogenes. the oversecretion of the these may lead to antiapoptotic proteins leading to cancer and also hyposecretion of the proapoptic protein also caus the cancer. The name Bcl-2 is derived form B-cell lymphoma 2.
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