A 35 year old Indian woman presented with a 6 year history of a hypopigmented pa

Question

A 35 year old Indian woman presented with a 6 year history of a hypopigmented patch on her left thigh and tender red bumps on her shins. The physical examination revealed erythematous nodules on anterior aspects of her legs, bilateral madarosis, and multiple nonhealing ulcrous lesion on the upper and lower extremities. The neurologic examination revealed glove and stocking anesthesia. The lepromin test was negative. The histopathologic examination of skin biopsy showed atrophic epidrmia and numerous acid-fast bacilli in globi and within macrophages. What is the best form of therapy of this patient?

A. Rifampin
B. Dapsone
C. Clofazimine
D. Triple Combination therapy

Explanation / Answer

The histopathologic examination of skin biopsy reveals atrophic epidermia with numerous acid fast bacilli in globi within macrophages. This indicates the patient contracted histoid leprosy or lepromatous leprosy with multibacillary lesions. The treatment of choice for this patient would be triple combination therapy with Rifampin, Dapsone and Clofazimine.

Hence, option D is correct.

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