A 33-year-old man had a screening colonoscopy, and was diagnosed with a right-si

Question

A 33-year-old man had a screening colonoscopy, and was diagnosed with a right-sided, mucinous colon cancer, with no other lesions or polyps seen. The reason he had a colonoscopy at such an early age is that his father and paternal uncle had colon cancers diagnosed by age 40. His paternal grandmother had ovarian and uterine cancers. A likely defect in the patient is a reduction in the ability to carry out which one of the following processes? uracil base removal from DNA replication forks. removal of thymine dimers correction of mismatched bases in newly synthesized DNA ligation of Okazaki fragments

Explanation / Answer

Deficieny of Mismatch repair system that corrects mismatched bases in newly synthesized DNA is the main cause of hereditary colorectal cancers like mucinous colorectal cancer. so answer is, correction of mismatched bases in newly synthesized DNA.

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