You work in a medical clinic that specializes in problems with metabolism and th

Question

You work in a medical clinic that specializes in problems with metabolism and the gastrointestinal tract.

In Part 1, you ran experiments to test different digestion process. In each experiment, starch, BAPNA (a synthetic protein) and vegetable oil (lipids) were present. In addition, specific reagents present in each of the experiments are listed in the table above: "+" indicates the presence of the reagent, "-" indicates the absence of the reagent. All samples were incubated at 37°C for 60 minutes.

A. For Part 1, indicate whether each of the IKI test, the Benedict’s test, the pepsin digestion test and the fat digestion test would be negative or positive. Explain your answers.

In Part 2, the four patients below presented with symptoms consistent with metabolic disorders. You ran tests to determine their levels of glucose, insulin, LDL-cholesterol and HDL-cholesterol. Your results are summarized in the table above.

B. For part 2, match each patient with their most likely “diagnosis”. Choose between the following conditions: normal, type 1 diabetes, type 2 diabetes, diabetes insipidus, dyslipidemia (i.e. abnormal cholesterol levels), cardiovascular disease, osteoporosis, osteopenia. Explain your answers

Explanation / Answer

Part A.

Experiment 1 will show positive tests for all- IKI test, Benedicts, and fat digestion except with pepsin. Pepsin is active at pH 2.

Experiment 2 will show positive test with only pepsin. Other enzymes will be inactive at such low pH.

Experiment 3 All will show negative results except with fat digestion.

Experiment 4. All results will be negative.

Part B.

Alexis is having Type 1 diabetes.

Olga is at a risk of developing type 2 diabetes, dyslipidemia

Martin is at risk of type 2 diabetes

Ben has type 1 diabetes

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