1.What is the role of carbonic anhydrase? 2. What determines if a hematopoietic

Question

1.What is the role of carbonic anhydrase?

2.

What determines if a hematopoietic stem cell will become an erythrocyte, leukocyte, or platelet?

Stem cell differentiation is governed by hematopoietic growth factors.

3.Where are the majority of erythrocytes broken down?

Stem cell differentiation is governed by erythropoietin.

4.Where does erythropoiesis occur?

spleen

5.

Which of the following is true of the erythrocytes?

to aid in the transport of carbon dioxide to aid in the conversion of oxygen to carbon dioxide to aid in the formation of carbon dioxide to aid hemoglobin's role in transporting carbon dioxide

Explanation / Answer

1.Carbonic anhydrase plays a role in respiration by aid Co2 transport out of the tissues

Carbonic anhydrase is an enzyme present in RBCsconverts CO2 to carbonic acid as it's transported by blood cells, before being converted back to carbon dioxide.

2. According to determinism theory of hematopoiesis, Colony-stimulating factors (CSF)and other factors of the haematopoietic microenvironment determine the cells to follow a certain path of cell differentiation.CSF are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell

3.Approximately 90% of RBC's are removed in the liver followed by  spleen, and lymph nodes. The other approximate 10% are hemolyzed within circulation.

4. Erythropoiesis is the process which produces red blood cells. It is stimulated by decreased O2 in circulation, which is detected by the kidneys, which then secrete the hormone erythropoietin.This hormone stimulates proliferation and differentiation of red cell precursors, which activates increased erythropoiesis in the hemopoietic tissues(BONE MARROW) resulting in RBC formation.

5. The most important function of red blood cells is the transport of oxygen (O2) to the tissues. The RBCs are dependent on anaerobic respiration for its energy needs because it do not have mitochondria for aerobic respiration. Majority of the proteins found in blood is synthesized by liver

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