1) What is not a way to turn down cytokine signaling? 2) Recombination of IG gen

Question

1) What is not a way to turn down cytokine signaling?

2) Recombination of IG gene segment serves to:

3) What controls the v heavy joining and D heavy but not J have the gene segments?

4) The classic complement pathway is initiated by interaction of C1 with A. antigen. B. factor B. C. antigen-IgG complexes. D. bacterial lipopolysaccharides

5) MHC one molecules present peptides antigens derived from a ______ compartment where as MHC two molecules present peptide antigens derived from a _____ compartment.

6) Considering only combinatorial joining of genes like mint and association of light and heavy chains how many different anti-body molecules potential he could be generated from germline DNA containing 500 V light and 4J light gene segments and 300 V heavy 15 D heavy and 4J have the gene segments

7) What is a transcription factor involved in signal transduction?

8) What time is used to refer to the strength of the interaction between a single action binding site of an antibody and a corresponding Ligand?

9) A positive feedback loop established between Mac pages and Dendric excels in infected tissue’s involves the secretion of_______ by the Macrophage and ______ by that NK cells.

10) Which of the following statements concerning class 1 MHC proteins is correct except

11) During IGV heavy recombination the processes that can’t you be at additional diversity at the third complementary determining region of IG variable regions include

Explanation / Answer

Ans 1:- cytokine like interleukin 2 or 6 are mai ly involved in the inflamotory pathaway and JAK STAT pathway is one of the most imp one of them.There Are two ways to tun down the cytokine singanalling....eitger give the receptor blockers or give the drugs that drugs that inhibit the production.we should prefer receptor blocker like basiliximab which bind to the interleukin 2 receptor and is used to prrvent transplant rejection.if we use that inhibit the production of cytokines like steroids so there may be the overall immunity problems because cytokimes are the end products of a common pathway that produce prostaglandins leucotrienns....the benificail prostagalndins will aslo get inhibitted.

Ans 2:-Ig recombination as the name suggest recombination if genetic sequence of immunoglubulin genes.it is also known as V(D)J RECOMBINATION.it occurs in early stages and only in developing lymphocites.it result in highly diverse repeators of immunoglobuLin's and T cell receptor.immunoglonukins receptors are found on B cell and T cell receptor are found on B cell.this diversity allows the recognition of nearly all the pathogens tht is bacteria virus parasites worms or cancel cells.

Ans 4:- antigen

An 5:- MHC 1......T8 cells

MHC 2 ......T4 cells

(Remember neumomic....producd should be 8 that is 1×8 or 2×4)

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