1. CASE: Susie G, is a 40-year-old female with Metabolic Syndrome, Obesity, IBS
ID: 3508343 • Letter: 1
Question
1. CASE:
Susie G, is a 40-year-old female with Metabolic Syndrome, Obesity, IBS (constipation predominant), Infertility, Fatigue, and PCOS. She drinks alcohol, craves sweets, has high cholesterol, high fasting blood sugar levels, insulin resistance, and elevated DHEAs levels. She has returned to you for a follow-up visit to discuss detoxification and how it may benefit her well-being.
1. a. Reviewing her abnormal OA results, you recall Susie had high levels of 8OHDG, Glucarate, and D-arabinitol, indicating DNA damage, elevated detoxification status and yeast overgrowth. What are you already doing to help out her pathways of detoxification from your previous appointment with her? Define which nutrients/supplements given for the abnormal OA results above support detoxification (ie. support phase I vs phase II detoxification, provide antioxidant support, etc). 1 point
1. b. Remembering Susie's original diet (see below), what foods/drinks should Susie avoid/ingest to assist detoxification. what further dietary/cooking adjustments could you make to Susie's diet that would reduce her intake of AGEs? 1/2 point
Her basic diet:
Breakfast - protein shake with berries/banana/almond milk or eggs and toast; 2 cups of coffee
Lunch – salad with chicken/Italian dressing or turkey sandwich with spinach/tomato/cheese/mustard on rye/whole wheat bread; water or herbal tea
Dinner – meat/chicken/fish/pork, carrots/green beans/broccoli/squash, potato/white rice/pasta; water, glass of wine
Snacks – none during day, chocolate/ice cream at night before bed
Usually orders out most of lunch/dinner meals because of late hours working
2.a. pick two ways you could NATURALLY (ie. using diet/nutrients/ supplements, NOT prescription drugs) help Susie inhibit or degrade AGEs and ALEs. Explain their mechanism of action (ie. antioxidant, enhance phase II detoxification, etc.). 1/2 point
2.b. What else could you do to nutritionally support her detoxification pathways? 1point
3.a. which nutrients are depleted/increased from alcohol ingestion and the mechanism by which this occurs. how many of Susie's symptoms/conditions and nutrient deficiencies could be related to alcohol ingestion? 1/2 point
3.b. provide 1-3 sentences on the benefits/detriments of alcohol. Knowing what you do about alcohol's effects on the body, how would you counsel clients on the use of alcohol? 1/2 point
Explanation / Answer
1a.For efficient phase two detoxification, the liver cells require sulphur-containing amino acids such as taurine and cysteine. The nutrients glycine, glutamine, choline and inositol are also required for efficient phase two detoxification.
Eggs and cruciferous vegetables (eg. broccoli, cabbage, Brussels sprouts, cauliflower), raw garlic, onions, leeks and shallots are all good sources of natural sulphur compounds to enhance phase two detoxification. Thus, these foods can be considered to have a cleansing action.
The following could be a supplement for treating osteoarthritis without harming. Green tea is an important detoxifying agent.
1b. Green tea (without sugar or milk) is good for detoxification since it is an antioxidant. It should be taken before eating anything else in the morning.
5-6 drops of lemon juice in warm water is good for losing weight, which could also be taken some time in the morning.
In her Lunch, whole wheat bread or chapatis of red wheat flour are fine. Cheese or other fatty substances should be minimal in her diet, since she is obese and also has diabetes. White bread should not be taken. Sandwich, if taken must be made of Wheat bread only. Non-vegetarian food has to be reduced for both Lunch and Dinner, and more vegetables have to be eaten for polycystic ovary syndrome.
Wine has to be strictly avoided. Chocolates and Ice-cream has also to be strictly avoided till she gets well.
Low sugar fruits could be taken in between her meals, if she feels Hungry.
2A. The average human digestive system produces approximately 3g of ethanol per day merely through fermentation of its contents. Catabolic degradation of ethanol is thus essential to life, not only of humans, but of almost all living organisms. In fact, certain amino acid sequences in the enzymes used to oxidize ethanol are conserved all the way back to single cell bacteria. Such a functionality is needed because all organisms actually produce alcohol in small amounts by several pathways, primarily along the fatty acid synthesis, glycerolipid metabolism,and bile acid biosynthesis pathways. If the body had no mechanism for catabolizing the alcohols, they would build up in the body and become toxic. Alcohol could be metabolized by sulfotransferase. Foods that help to decrease the weight would also help in this case, since in this case there will be less toxins to be metabolized.
2B. If the phase one and two detoxification pathways become overloaded, there will be a build up of toxins in the body. Many of these toxins are fat soluble and incorporate themselves into fatty parts of the body where they may stay for years, if not for a lifetime. The brain and the endocrine (hormonal) glands are fatty organs, and are common sites for fat-soluble toxins to accumulate. This may result in symptoms of brain dysfunction and hormonal imbalances, such as infertility, breast pain, menstrual disturbances, adrenal gland exhaustion and early menopause. Many of these chemicals (eg. pesticides, petrochemicals) are carcinogenic and have been implicated in the rising incidence of many cancers.
It has been evidenced that Bitter herbs could improve phase 1 and 2 detoxification. Bitter herbs have been known for a long time to reduce the risk of diabetes, recent evivences also say the same. A range of physiological responses occur following stimulation of the bitter receptors of the tongue. The bitter taste stimulates the specific bitter taste buds at the back of the tongue to stimulate the parasympathetic nervous system to trigger a number of reflexes. These reflexes are important to the digestive process and general health.
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