A 30 year old woman complains of impaired speech and frequent aspiration of food

Question

A 30 year old woman complains of impaired speech and frequent aspiration of food. Physical examination reveals Diplopoda and drooping eyelids. A mediastinal mass is removed and diagnosed as thymoma. The symptoms of muscle weakness in this patient are caused by antibodies directed against which of the following cellular components?
Calcium channel
Acetylcholine receptor
Rheumatic factor
Thyroid-stimulating hormone receptor
Desmoglein-3 A 30 year old woman complains of impaired speech and frequent aspiration of food. Physical examination reveals Diplopoda and drooping eyelids. A mediastinal mass is removed and diagnosed as thymoma. The symptoms of muscle weakness in this patient are caused by antibodies directed against which of the following cellular components?
Calcium channel
Acetylcholine receptor
Rheumatic factor
Thyroid-stimulating hormone receptor
Desmoglein-3
Calcium channel
Acetylcholine receptor
Rheumatic factor
Thyroid-stimulating hormone receptor
Desmoglein-3

Explanation / Answer

Acetyl choline receptors

Myasthenia gravis is an autoimmune disease caused by production of antibodies against acetylcholine receptors. This causes muscle weakness throughout the body. Weak pharyngeal and facial muscles causes difficulty in chewing, and swallowing that some times causes aspiration of food. Drooping eyelids is an occular symptom of myasthenia gravis. Failure of respiratory muscles may cause resiratory failure and death. Thymoma and hyperplasia of thymus are associated diseases of myashenia gravis.

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