Item 2 In many organisms, a substantial fraction of cytosine contained in DNA is

Question

Item 2 In many organisms, a substantial fraction of cytosine contained in DNA is enzymatically modified after DNA replication to 5-methylcytosine. The DNA sequence of a single strand of a portion of a wild-type gene and that of 5 spontaneous mutant alleles of the gene are shown below. wild-type: 5? ACTCAGTCGGCCGCCACG 3? allele #1: 5? ACTCACTCGGCCGCCACG 3? allele #2: 5? ACTCAGTTGGCCGCCACG 3? allele #3: 5? ACTCAGTCGGCCGCCGCG 3? allele #4: 5? ACTCAGACGGCCGCCACG 3? allele #5: 5? ACTCAGTCGGCCACCACG 3? Part A Which of the alleles might have arisen following spontaneous deamination of 5-methylcytosine? Enter your answer as a number (not word). If there is more than one possible allele, enter your answer in numerical order, without spaces or commas. For example: 1235

Explanation / Answer

Allele # 2: Deamination of 5-methylcytosine (8th nucleotide in wild type allele) to Thymine (mutant allele)..

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