You have identified a novel mutant allele for the HiBrn8 gene leading to decreas

Question

You have identified a novel mutant allele for the HiBrn8 gene leading to decreased response to stimuli by the brown bear during hibernation. You have obtained the sequence for wild type and mutant alleles for ABCR. The underlined portion is an intron.

       Wild type ABCR:             

5?-ATTACGATGACCGGGAAGGTACCCTAATTGAGCAGGGATTTCTGAAAAAATAACCC-3?

Mutant ABCR:   

5?-ATTACGATGACCGGGAAAGTACCCTAATTGAGCAGGGATTTCTGAAAAAATAACCC-3?

a.      Circle the mutation and determine what type of mutation it is. (2 points)

b.     You have determined that the intron does not get removed from the mRNA for your mutant allele. How might this affect overall structure of the mutant protein compared to wild type? (3 pts)

c.      Draw a square around the translation stop sites in the wild type and the mutant forms of the protein. (2 pts)

Explanation / Answer

a) Wild type ABCR:             

5

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