You have identified a novel protein that associates with the plasma membrane. Yo

Question

You have identified a novel protein that associates with the plasma membrane. You do not know whether this protein is a peripheral or a transmembrane protein. You therefore analyze the primary amino acid sequence (listed in the three letter code) for the presence of a transmembrane domain.

Met - Asp - Leu - Lys - Ile - Pro - Gly - Val - Glu - Arg - Met - Phe - Leu - Ile - Ser - Lys - Gly - Thr - Asp - Tyr - His - Asn - Gln - Val - Met - Val - Gly - Pro - Asp - Glu - Ala - Ala - Ala - Val - Met - Arg - Trp - Cys - Met - Phe - Ile - Val - Val - Val - Thr - Val - Glu - Glu - Gly - Asp - Met - Val - Ala - Ile - Ile - Val - Leu - Pro - Lys - Arg - Trp - Tyr - Phe - Ala - Gln - Tyr - Ala - Val - Leu - Ile - Leu - Met - Ala - Trp - Leu - Val - Phe - Val - Ile - Leu - Ala - Arg - Lys - His - Ala - Val - Ile - Leu - Trp - Tyr - Ala - Gly - Gln - Gly - Asn - Arg - His - Cys - Lys - Met

How many potential transmembrane domains can you identify in this protein?

a) 0

b) 1

c) 2

d) 3

e) 4

Explanation / Answer

Transmembrane proteins generally contains Hydrophobic amino acids with very little Hydrophilic amino acids.

Methionine, Proline, Tryptophan, Phenylalanine, Cysteine, Glycine, Alanine, Valine, Leucine and Isoleucine are hydrophobic amino acids.

So the number of potential domains acording to my calculation will be 4.

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