Girard et al. (A-6) conducted a study to identify prognostic factors of improved
ID: 3240475 • Letter: G
Question
Girard et al. (A-6) conducted a study to identify prognostic factors of improved survival after resection of isolated pulmonary metastases (PM) from colorectal cancer. Among the data collected were the survival (in months), status (dead=1 or dead=0, if alive) and dichotomized number of resected PM (ResectedPM=1 or ResectedPM =’>1’) for 77 patients who underwent complete resection at the first thoracic operation.
What is the median survival (with corresponding confidence interval) in the group with ResectedPM=1 and in the group ResectedPM =’>1’?
What is the estimated hazard ratio (with corresponding confidence interval) associated with the difference in survival between patients with ResectedPM=1 vs. ResectedPM =’>1’? What is the meaning?
Stratum 1: ResectedPM-1 Product-Limit Survival Estimates Survival Standard Number Number MONTHS Survival Failure Error Failed Left 0 0 0 46 1.0000 0.000 0.9783 002 17 0.0215 1 45 2.000 3000 0.9560 0.0440 0.0304 5.000 10.000 3 42 0.9116 0.0884 0.0422 14000 0.8893 0.1107 0.0467 51 401 61 15.000 7 38 15.000 0.8449 0.1551 0.0539 16000 0.8226 0.1774 0.0569 37 91 36 17.000 10 35 0.7782 0.2218 0.0619 17.000 0.7559 0.2441 0.0640 18.000 0.7337 0.2663 0.0659 19.000 19,000 12 32 12 24000 12 301 24.000 13 26.000 0.6848 0.3152 0.0700 26.000 16 26 0.6359 0.3641 0.0730 27.000 0.6114 0.3886 0.0742 241 29.000 0.5859 0.4141 0.0753 33.000 18 35.000 0.5593 04407 0.0765 19 21 37.000 39.000 19 20 40,000 191 191 0.5299 0.4701 0.0779 20 17 42.000 R 43.000 43.000 0.4675 0.5325 0.0803 45.000 14Explanation / Answer
Answer:
What is the median survival (with corresponding confidence interval) in the group with ResectedPM=1 and in the group ResectedPM =’>1’?
Median survival in the group with ResectedPM=1 is 43 (27, - ).
Median survival in the group ResectedPM =’>1’ is 23 (15, 29).
What is the estimated hazard ratio (with corresponding confidence interval) associated with the difference in survival between patients with ResectedPM=1 vs. ResectedPM =’>1’? What is the meaning?
Estimated hazard ratio 0.473 (0.272, 0.821).
1-0.473=0.527
The risk of death is 52.7% less for ResectedPM =’>1’ group compared to ResectedPM=1.
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