Girard et al. (A-6) conducted a study to identify prognostic factors of improved
ID: 3240474 • Letter: G
Question
Girard et al. (A-6) conducted a study to identify prognostic factors of improved survival after resection of isolated pulmonary metastases (PM) from colorectal cancer. Among the data collected were the survival (in months), status (dead=1 or dead=0, if alive) and dichotomized number of resected PM (ResectedPM=1 or ResectedPM =’>1’) for 77 patients who underwent complete resection at the first thoracic operation.
What are the study questions?
What is the outcome of interest (dependent variable)?
What are the predictors of outcome (independent variables)?
What statistical model was used?
What statistical hypotheses were tested to address the study questions?
Were the null hypotheses rejected at the level 0.05?
What conclusions should be made based on the statistical analysis results?
Stratum 1: ResectedPM-1 Product-Limit Survival Estimates Survival Standard Number Number MONTHS Survival Failure Error Failed Left 0 0 0 46 1.0000 0.000 0.9783 002 17 0.0215 1 45 2.000 3000 0.9560 0.0440 0.0304 5.000 10.000 3 42 0.9116 0.0884 0.0422 14000 0.8893 0.1107 0.0467 51 401 61 15.000 7 38 15.000 0.8449 0.1551 0.0539 16000 0.8226 0.1774 0.0569 37 91 36 17.000 10 35 0.7782 0.2218 0.0619 17.000 0.7559 0.2441 0.0640 18.000 0.7337 0.2663 0.0659 19.000 19,000 12 32 12 24000 12 301 24.000 13 26.000 0.6848 0.3152 0.0700 26.000 16 26 0.6359 0.3641 0.0730 27.000 0.6114 0.3886 0.0742 241 29.000 0.5859 0.4141 0.0753 33.000 18 35.000 0.5593 04407 0.0765 19 21 37.000 39.000 19 20 40,000 191 191 0.5299 0.4701 0.0779 20 17 42.000 R 43.000 43.000 0.4675 0.5325 0.0803 45.000 14Explanation / Answer
Answer:
Girard et al. (A-6) conducted a study to identify prognostic factors of improved survival after resection of isolated pulmonary metastases (PM) from colorectal cancer. Among the data collected were the survival (in months), status (dead=1 or dead=0, if alive) and dichotomized number of resected PM (ResectedPM=1 or ResectedPM =’>1’) for 77 patients who underwent complete resection at the first thoracic operation.
What are the study questions?
To identify prognostic factors of improved survival after resection of isolated pulmonary metastases (PM) from colorectal cancer.
What is the outcome of interest (dependent variable)?
survival time(in months).
What are the predictors of outcome (independent variables)?
number of resected PM
What statistical model was used?
Survival analysis, Cox proportional hazards model is used.
What statistical hypotheses were tested to address the study questions?
number of resected PM affects the survival of the patients.
Were the null hypotheses rejected at the level 0.05?
Calculated chi square=7.0691, P=0.0078 which is < 0.05 level of significance.
Ho is rejected.
What conclusions should be made based on the statistical analysis results?
There is sufficient evidence that number of resected PM affects the survival of the patients
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