need some help with this problem, thank you Problem #2 (50 points). Using a MinI
ID: 3165437 • Letter: N
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need some help with this problem, thank you
Problem #2 (50 points). Using a MinION shipped on the Mars 2020 mission, you are thrilled to discover life existed at one time on Mars! Upon careful analysis of some Martian DNA, you realize that an unusual third nucleotide pair W-Z exists in addition to the standard A-T and G-C pairs. You manage to extract a 30-nucleotide stretch of a single Martian DNA strand and determine its nucleotide sequence, after originally not knowing it at all. Most of the time, you find that w pairs with Z, A pairs with T, and G pairs with C. However, you do find that 20.0% of the time a Z nucleotide can pair with a T nucleotide. The nucleotide sequence that you were able to analyze is given below. How much information content exists in this sequence? Explain your logic and show your calculations. Following question #1 above, give a plausible H-bonding designation for the base-pairing surfaces of the W and Z nucleobases. Lastly, provide one reason why the Martian genetic structure might have led to the extinction of all Martian life. 5 5-CATZGWACATCATWCWZZGATTZWWATWAG-3Explanation / Answer
According to the information, W can bind with Z but a Z can also bind to A 20% times. Thus, the total number of different nucleotides in the sequence are given as below:
A: 7
T: 6
G: 3
C: 4
W: 6
Z: 4
Following information can be extracted from this data:
It can be seen from the data and the information that the uneven distribution of A, T, W and Z residues demonstrates that the binding is not specific in this case. This causes severe structural destability in the DNA thus leading to non-preservance of the genome. The replication of such genome is highly error prone and thus onset of random mutation must have lead to extinction of these species.
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