A 21 year old male was a volunteer blood donor. He passed both physical and writ

Question

A 21 year old male was a volunteer blood donor. He passed both physical and written criteria for donation. All infectious disease testing was negative.

His blood type results are as follows:

Anti-A Anti-B A1 cell B cell

0 4+ 0 0

What is the discrepancy?

i. Negative results with A1 cell

ii. 4+ agglutination with anti-B

iii. Negative results with B cell

iv. No prolems

The following extra typing was performed, how should it be interpreted?

Anti-A1 lectin A2 cells Anti-A,B O cells Patient cells

0 0 4+ 0 0

i. The donor has weak antibodies

ii. The donor is an AsubB

iii. The donor has atypical antibody

iv. The donor has acquired B antigen

What follow up testing would be the most helpful?

i. Use a different lot of reverse type cells

ii. Incubate the blood type at 4C and re -test

iii. Perform further antibody testing

iv. Perform adsorption/elution studies for B antigen

Explanation / Answer

What is the discrepancy?

i. Negative results with A1 cell: This is right answer because if a person anti B , it must be agglutinate with A1 cell surface antigen but here A1 cell is 0, It means there is false negative result and further investigation should be needed.

The following extra typing was performed, how should it be interpreted?

i. The donor has weak antibodies: donor is 'O' secretor so that muast have weak antibody to not agglutinate.

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