PART D: A group of 1,000 female college seniors from a large university were ‘fo

Question

PART D: A group of 1,000 female college seniors from a large university were ‘followed’ for 20 years to investigate the whether the use of oral contraceptives increases women’s risk of developing blood clots (thrombo-embolism). Of these females, 592 were oral contraceptive users and 408 did not use oral contraceptives. Among oral contraceptive users, 48 developed blood clots. Among non-users, 22 developed blood clots. None of the females had clots when the study began. Q1: Calculate the cumulative incidence of developing blood clots for women in the study. Q2: The 1,000 participating women contributed a total of 15,249 person-years of follow up during the study. Using this and the data described in the scenario, calculate the incidence rate for developing blood clots for women in the study. (per 10,000 persons per year) Q3: Since there are only 15,249 person years of follow-up, it is clear that not everyone completed 20 years of follow-up. List 2 reasons why some members of the cohort may not have completed 20 years of follow-up

Explanation / Answer

Q1)

Oral Users developing blood clots = 48

Non Oral Users developing blood clots = 22

So, Cumulative incidence = 48 + 22 = 70

Q2)

Number of Follow ups = 15249

Total persons = 10000

So, Incidence rate(IR) = (cumulative incidence / Number of Follow ups) * Total persons

IR = (70/15249) * 10000

IR = 45.904 = 46

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