Any two of you typically have an estimated 0.1% difference in your nucleotide se
ID: 303494 • Letter: A
Question
Any two of you typically have an estimated 0.1% difference in your nucleotide sequences, which is equivalent to about 3 million nucleotide differences (3 billion base pairs in the human genome). These differences are the basis of the SNPs used to construct genetic linkage maps. Some of these SNPs actually lie in the region of the DNA that codes for the protein, yet they have no effect on the phenotype of individuals carrying the SNP on both homologous chromosomes. Of the following answer which is the most probable??
C) Amino acid substitutions in some cases will happen but they will still permit the eventual protein to function.
A) In all cases they code for the same amino acid., and that is why these are tolerated.Explanation / Answer
Answer b.) The wobble nature of genetic code can tolerate these differences. It is because of the degeneracy of the genetic code which supports wobble hypothesis and for that reason if after the change in nucleotide sequence at one position does effect the genetic code for amino acid. This is categorised under synonymous change which doesn't effect the change in polypeptide sequence and phenotype of the individual.
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